ACTIVE GRANTS

Translating Metabolic Responses to Mechanical Insult into Early Interventions to Prevent PTOA – Department of Defense Congressionally Directed Medical Research Programs – W81XWH-18-1-0658
09/01/2018-08/31/2022 Total Project Costs: $9,999,762
09/01/2018-08/31/2019 Annual Direct Costs: $1,510,665
Joseph A. Buckwalter, MD, Principal Investigator

    Project 1: Small-scale early phase clinical trial of amobarbital to reduce PTOA risk in tibial pilon fractures
    Project Leads: J. Lawrence Marsh, MD and James C. Torner,

    Project 2: Integrating pathomechanical PTOA risk into clinical decision-making following IAF
    Project Leads: Donald D. Anderson, PhD and Jason M. Wilken, MPT, PhD

    Project 3: Supplementing joint lubrication as an adjunct to amobarbital treatment
    Project Leads: James A. Martin, PhD and Aliasger Salem, PhD

    Project 4: Correlation of cartilage mechanics with chondrocyte mitochondrial dysfunction targeted by amobarbital
    Project Leads: Jessica E. Goetz, PhD and Mitchell C. Coleman, PhD

Benchmarking Expert Performance to Establish Competency in Wire Navigation – Orthopaedic Research and Education Foundation / American Board of Orthopaedic Surgeons
09/01/2018-08/31/2021 Total Project Costs: $300,000
09/01/2018-08/31/2019 Total Project Costs: $100,000
Matthew D. Karam, M.D. and Geb W. Thomas, PhD, Principal Investigators
Donald D. Anderson, Ph.D.,  Investigator

Accelerating Osteoarthritis Clinical Trials Through Responsive Low-Dose Standing CT Imaging – R01 AR071648
08/15/2018-06/30/2021 Total Project Costs: $606,816 (UI Subaward: $175,133)
08/15/2018-06/30/2019 Annual Direct Costs: $150,148 (UI Subaward: $36,499)
Neil A. Segal, MD, Principal Investigator at University of Kansas Medical Center Research Institute, Inc.
Donald D. Anderson, PhD, Subaward Principal Investigator

The Design and Validation of a Wire Navigation Simulator for Pediatric Supracondylar Humerus Fractures – Pediatric Orthopaedic Society of North America
06/01/2018-05/31/2020 Total Project Costs: $49,701
06/01/2018-05/31/2019 Annual Direct Costs: $24,693
Heather R. Kowalski, M.D. and Geb W. Thomas, PhD, Principal Investigators
Donald D. Anderson, Ph.D. and Matthew D. Karam, MD, Investigators

Simulation to Support Competency-Based Training in Orthopedic Trauma – Agency for Healthcare Research and Quality R18 HS025353
09/30/2017-07/31/2022 Total Project Costs: $1,876,254
08/01/2018-07/31/2019 Annual Direct Costs: $264,950
Donald D. Anderson, Ph.D. and Geb W. Thomas, PhD, Principal Investigators
Matthew D. Karam, MD, Clarence D. Kreiter, PhD, J. Lawrence Marsh, MD, Investigators

Joint Contact Stress as a Tool for Clinical Decision Making in Periacetabular Osteotomy – Orthopaedic Research and Education Foundation
07/01/2017-06/30/2020 Total Project Costs: $209,804
07/01/2018-06/30/2019 Annual Direct Costs: $61,103
Michael C. Willey, MD and Jessica E. Goetz, PhD, Principal Investigators
Donald D. Anderson, PhD, Investigator
Catherine Fruehling, BS, Research Assistant
J. Lawrence Marsh, MD, Consultant

Does Contact Stress Better Predict PTOA and Patient Outcomes in Patients with Displaced Acetabular Fractures Following ORIF? – Orthopaedic Trauma Association
06/01/2017-08/31/2018 Total Project Costs: $20,000
06/01/2017-08/31/2018 Annual Direct Costs: $20,000
Tyler L. CarlLee, MD, Resident Principal Investigator
Donald D. Anderson, PhD, Co-Principal Investigator
Michael C. Willey, MD, Co-Principal Investigator/Mentor

An Imaging Framework for Clinically Testing New Treatments to Prevent Post-Traumatic OA – Orthopaedic Trauma Association
01/01/2017-12/31/2019 Total Project Costs: $79,982
01/01/2018-12/31/2018 Annual Direct Costs: $39,991
Donald D. Anderson, PhD, Principal Investigator
J. Lawrence Marsh, MD, Co-Principal Investigator
Bruce Sangeorzan, MD, Thomas Higgins, MD, Investigators

Engineering Endogenous Cartilage Repair - Arthritis Foundation
01/01/2016-01/01/2019 Total Project Costs: $961,381
James A. Martin, PhD, Principal Investigator
Jessica E. Goetz, PhD, Investigator

Pathomechanics of Post-Traumatic OA Development in the Military Following Articular Fracture – Department of Defense Congressionally Directed Medical Research Programs – W81XWH-15-2-0087
09/30/2015-09/29/2018 Total Project Costs: $755,257
Donald D. Anderson, PhD, Principal Investigator
Jessica C. Rivera, MD, Co-Principal Investigator
J. Lawrence Marsh, MD, Anthony Johnson, MD, Investigators

Joint Distraction Treatments of Intra-Articular Fracture Induced Post-Traumatic Osteoarthritis in a Large Animal Model – Department of Defense Peer Reviewed Orthopaedic Research Program – W81XWH-15-1-0642
09/30/2015-08/29/2019 Total Project Costs: $1,590,922
Jessica E. Goetz, PhD, Principal Investigator
Douglas C. Fredericks, BS, James A. Martin, PhD, Mitchell C. Coleman, PhD, Michael C. Willey, MD, Investigators
Thomas E. Baer, BS, M. James Rudert, PhD, Engineers